What are some good metallica/slayer/megadeth type lead guitar settings?

Hello I have a vlh 15 amp with an eminence speaker and it has a megadrive/clean mix and a straight clean bypass channel (megadrive has gain,tone,and volume and clean has low,mid,high,reverb and reverb. My effects are Jekyll and Hyde (overdrive/distortion pedal. An ibanez ts808 tube screamer. A BOSS CH-1 super chorus. A crybaby standard wah and a Jackson v I forget what series I was curious about suggested settings for all these not factory settings unless you think they sound best I was trying to play rhythm and lead together but if that's not possible I don't want to but a multi-effects board so please don't suggest any I don't like them and also thanks for all the answers.